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Index > Protein center > Nox4(Gene name) > Mouse
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  • Nox4 (Gene name),
  • NADPH oxidase 4 (Protein name ),  NOX4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Nox4(Renox);
    Protein name:
    NADPH oxidase 4;
    Alternative:
    Kidney superoxide-producing NADPH oxidase;Kidney oxidase-1(KOX-1);Superoxide-generating NADPH oxidase 4;Renal NAD(P)H-oxidase;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with, relocalizes and stabilizes CYBA/p22phox. Interacts with TLR4. Interacts with protein disulfide isomerase.
    Function:
    Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein Cell junction focal adhesion Cell membrane May localize to plasma membrane and focal adhesions.
    Protein Attributes:
    Sequence length:
    578
    Sequence:
    50:
    MAVSWRSWLA | NEGVKHLCLL | IWLSLNVLLF | WKTFLLYNQG | PEYYYIHQML | 
    100:
    GLGLCLSRAS | ASVLNLNCSL | ILLPMCRTVL | AYLRGSQKVP | SRRTRRLLDK | 
    150:
    SKTLHITCGV | TICIFSGVHV | AAHLVNALNF | SVNYSEDFLE | LNAARYQNED | 
    200:
    PRKLLFTTIP | GLTGVCMVVV | LFLMVTASTY | AIRVSNYDIF | WYTHNLFFVF | 
    250:
    YMLLLLHVSG | GLLKYQTNVD | THPPGCISLN | QTSSQNMSIP | DYVSEHFHGS | 
    300:
    LPRGFSKLED | RYQKTLVKIC | LEEPKFQAHF | PQTWIWISGP | LCLYCAERLY | 
    350:
    RCIRSNKPVT | IISVINHPSD | VMELRMIKEN | FKARPGQYII | LHCPSVSALE | 
    400:
    NHPFTLTMCP | TETKATFGVH | FKVVGDWTER | FRDLLLPPSS | QDSEILPFIH | 
    450:
    SRNYPKLYID | GPFGSPFEES | LNYEVSLCVA | GGIGVTPFAS | ILNTLLDDWK | 
    500:
    PYKLRRLYFI | WVCRDIQSFQ | WFADLLCVLH | NKFWQENRPD | FVNIQLYLSQ | 
    550:
    TDGIQKIIGE | KYHTLNSRLF | IGRPRWKLLF | DEIAKCNRGK | TVGVFCCGPS | 
    578:
    SISKTLHSLS | NRNNSYGTKF | EYNKESFS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    String:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse NADPH oxidase 4
    Cat.:
    E1488h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse NADPH oxidase 4
    Cat.:
    E1488r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse NADPH oxidase 4
    Cat.:
    E1488m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse NADPH oxidase 4
    Cat.:
    U1488h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse NADPH oxidase 4
    Cat.:
    U1488m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse NADPH oxidase 4
    Cat.:
    U1488r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse NADPH oxidase 4
    Cat.:
    P1488Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse NADPH oxidase 4
    Cat.:
    P1488Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse NADPH oxidase 4
    Cat.:
    P1488Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse NADPH oxidase 4
    Monoclonal Antibody for Mouse NADPH oxidase 4
    Monoclonal Antibody for Mouse NADPH oxidase 4
    Protein for Mouse NADPH oxidase 4
    Protein for Mouse NADPH oxidase 4
    Protein for Mouse NADPH oxidase 4

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of renox, an NAD(P)H oxidase in kidney."
      Geiszt M. , Kopp J.B. , Varnai P. , Leto T.L.
      Proc. Natl. Acad. Sci. U.S.A.97:8010-8014(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;ENZYME REGULATION
      tissue: Kidney.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "A new superoxide-generating oxidase in murine osteoclasts."
      Yang S. , Madyastha P. , Bingel S. , Ries W. , Key L.
      J. Biol. Chem.276:5452-5458(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
    4. 4.
      Banfi B. , Maturana A. , Demaurex N. , Krause K.-H.
      Submitted (2000-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
      strain: C57BL/6J.
      tissue: Heart.
      tissue: Liver.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      strain: FVB/N.
      tissue: Kidney.
    7. 7.
      "Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia."
      Suliman H.B. , Ali M. , Piantadosi C.A.
      Blood104:43-50(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    8. 8.
      "Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone."
      Ding Y. , Chen Z.-J. , Liu S. , Che D. , Vetter M. , Chang C.-H.
      J. Pharm. Pharmacol.57:111-116(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    9. 9.
      "Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia."
      Vallet P. , Charnay Y. , Steger K. , Ogier-Denis E. , Kovari E. , Herrmann F. , Michel J.-P. , Szanto I.
      Neuroscience132:233-238(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
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